Very interesting! Where does low carb high fat land on this for you? I have been on a mainly carnivore diet and I’ve resolved a lot of issues: allergies, tendonitis, and high blood pressure. But, my HbA1c started to go up, which surprised me. I attributed it to finishing my residency, and I have to take new tests now that I have gotten my circadian rythm in shape (or at least better). If it where to continue to be high, where would yo go? I find this very interesting, and thanks for the information provided! I know its a lot, but if you want to chat I’d love to do it
TY! What I’ve learned from years of experimenting and studying metabolism is that every restrictive system follows the same arc. Carnivore, vegan, keto - the first phase reduces irritants so symptoms calm fast and people feel quick relief. That’s why symptoms like allergies and tendon issues settle. With time it drives metabolism into a low-glycogen, low-T3, high-cortisol state. (That shift is enough to move A1c upward btw). The timeline varies, but the direction is always the same. Short term relief. Long term rigidity. The pattern repeats across restrictive diets because the body adapts the same way when fuel flexibility disappears. I’ve posted about this pattern on X many times.
If your A1c is still elevated, I’d look at Free T3, morning cortisol, triglycerides, and GGT together. Those four show whether the diet pushed you toward thyroid slowdown, liver load, or a stress-driven pattern.
No. Not even close. I honestly cannot see how you arrived at that conclusion. Reta does not fix insulin resistance. It makes you eat less, so the insulin number may fall for a moment, but the systems that create insulin resistance stay exactly the same. Thyroid output stays low, the liver stays congested, mitochondrial handling stays weak etc. Nothing upstream improves. And once you stop, insulin rebounds fast because the biology was never repaired.
My article outlined six upstream drivers of insulin resistance (and showed how to correct them naturally). Comparing all of that to an experimental drug that may lower the number by suppressing appetite is not the same category.
There is not a single trial showing Reta restores thyroid output, improves hepatic insulin clearance, strengthens mitochondrial function or repairs any upstream metabolic function. A lower insulin number from eating less is not a metabolic restoration. If you think those studies prove system repair then you do not understand what the trials are measuring and/or the biology behind it.
Very interesting! Where does low carb high fat land on this for you? I have been on a mainly carnivore diet and I’ve resolved a lot of issues: allergies, tendonitis, and high blood pressure. But, my HbA1c started to go up, which surprised me. I attributed it to finishing my residency, and I have to take new tests now that I have gotten my circadian rythm in shape (or at least better). If it where to continue to be high, where would yo go? I find this very interesting, and thanks for the information provided! I know its a lot, but if you want to chat I’d love to do it
TY! What I’ve learned from years of experimenting and studying metabolism is that every restrictive system follows the same arc. Carnivore, vegan, keto - the first phase reduces irritants so symptoms calm fast and people feel quick relief. That’s why symptoms like allergies and tendon issues settle. With time it drives metabolism into a low-glycogen, low-T3, high-cortisol state. (That shift is enough to move A1c upward btw). The timeline varies, but the direction is always the same. Short term relief. Long term rigidity. The pattern repeats across restrictive diets because the body adapts the same way when fuel flexibility disappears. I’ve posted about this pattern on X many times.
If your A1c is still elevated, I’d look at Free T3, morning cortisol, triglycerides, and GGT together. Those four show whether the diet pushed you toward thyroid slowdown, liver load, or a stress-driven pattern.
Thanks! Great information, I’ll update when I get labs done. Regards from Chile
Wishing you good luck with the labs! sending regards back to Chile.
Τhank your for sharing, excellent, simple to understand and follow.🙏
Thank you, Ed!
What an awesome article. Very well researched and love the detailed treatment plans for each of the possible causes. Thanks for writing this up.
Thank you, Aaron!
Thanks so much, this was really informative
Thank you, Caz!
I feel like everything that you share can be fixed with Retatrudite
No. Not even close. I honestly cannot see how you arrived at that conclusion. Reta does not fix insulin resistance. It makes you eat less, so the insulin number may fall for a moment, but the systems that create insulin resistance stay exactly the same. Thyroid output stays low, the liver stays congested, mitochondrial handling stays weak etc. Nothing upstream improves. And once you stop, insulin rebounds fast because the biology was never repaired.
My article outlined six upstream drivers of insulin resistance (and showed how to correct them naturally). Comparing all of that to an experimental drug that may lower the number by suppressing appetite is not the same category.
That’s actually not true, it’s currently going through trials and all the studies show that that’s exactly what it does
There is not a single trial showing Reta restores thyroid output, improves hepatic insulin clearance, strengthens mitochondrial function or repairs any upstream metabolic function. A lower insulin number from eating less is not a metabolic restoration. If you think those studies prove system repair then you do not understand what the trials are measuring and/or the biology behind it.